Publications by authors named "Z Vuckovic"
High-resolution cryo-electron microscopy (cryo-EM) requires costly 200- to 300-keV cryo-transmission electron microscopes (cryo-TEMs) with field emission gun (FEG) sources, stable columns, constant-powered lenses, autoloader, and direct electron detectors (DED). Recent advances in 100-keV imaging with the emergence of sub-200-keV optimized DED technology promises the development of more affordable cryo-TEMs. So far, 100-keV imaging has required microscopes with FEG sources.
View Article and Find Full Text PDFObjectives: Evaluate the inter-examiner reliability of pain provocation tests for hip adductors (palpation, stretch and resistance) and for pubic symphysis (palpation) in athletes with longstanding groin pain, and to determine the prevalence of positive tests.
Design: Inter-examiner reliability.
Setting: Orthopaedic and sports medicine hospital.
Article Synopsis
- - The M muscarinic acetylcholine receptor (M mAChR) is a key target for drug development due to its role in managing psychosis, cognition, and addiction, with xanomeline showing promise in improving symptoms of schizophrenia in clinical trials.
- - Recent research revealed the cryo-EM structure of xanomeline bound to the M mAChR, showing that two xanomeline molecules can simultaneously bind to different sites on the receptor.
- - These findings suggest that xanomeline functions as both an orthosteric and allosteric ligand, enhancing our understanding of its complex pharmacology and how ligands can interact with GPCRs for therapeutic purposes.
Allosteric modulation of G protein-coupled receptors (GPCRs) is a major paradigm in drug discovery. Despite decades of research, a molecular-level understanding of the general principles that govern the myriad pharmacological effects exerted by GPCR allosteric modulators remains limited. The M muscarinic acetylcholine receptor (M mAChR) is a validated and clinically relevant allosteric drug target for several major psychiatric and cognitive disorders.
View Article and Find Full Text PDFObjectives: To evaluate the interexaminer reliability of abdominal palpation and resistance tests in athletes with longstanding groin pain, and to identify the prevalence of positive clinical tests in athletes classified with inguinal-related groin pain.
Methods: Male athletes (18-40 years) with longstanding groin pain were prospectively recruited between March 2019 and October 2020 at a sports medicine hospital. Two examiners performed history taking and standardised clinical examination (including abdominal palpation, scrotal invagination and abdominal resistance tests) blinded to each other's findings.