Publications by authors named "Z Vanickova"
Fibroblast activation protein (FAP) has been extensively studied as a cancer biomarker for decades. Recently, small-molecule FAP inhibitors have been widely adopted as a targeting moiety of experimental theranostic radiotracers. Here we present a fast qPCR-based analytical method allowing FAP inhibition screening in a high-throughput regime.
View Article and Find Full Text PDFThe significance of extraesophageal reflux as a risk factor in lung adenocarcinoma has been understudied. In this study, we investigated whether extraesophageal reflux leads to higher pepsin concentrations in bronchoalveolar lavage (BAL) in patients with lung adenocarcinoma compared to controls. Subjects were recruited from non-smoker patients (lifelong non-smokers and ex-smokers with more than 5 years of non-smoking history) who had undergone bronchoscopy due to pulmonary abnormalities on a CT scan and met the inclusion criteria.
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- Identified a new variant (p.R79W) in the ALG5 gene linked to late-onset ADPKD in two Irish families, highlighting its impact on kidney damage and fibrosis.
- Employed whole exome and targeted sequencing along with immunohistochemistry to examine genetic segregation and protein abnormalities in kidney biopsies from affected individuals.
- Found that ALG5 dysfunction disrupts the maturation and transport of uromodulin, leading to changes in kidney structure and function, thereby confirming ALG5's role in late-onset ADPKD.
Brain metastases are a very common and serious complication of oncological diseases. Despite the vast progress in multimodality treatment, brain metastases significantly decrease the quality of life and prognosis of patients. Therefore, identifying new targets in the microenvironment of brain metastases is desirable.
View Article and Find Full Text PDFObjective: The aim of this prospective observational study was to investigate the effects of a novel Wim Hof psychophysiological training program on stress responses and hormone release in healthy participants during an Antarctic expedition.
Methods: All members of an Antarctic expedition were included in the study. The participants were healthy volunteers allocated to an intervention group (n = 6) and a control group (n = 7).