[The polymorphism of DNA repair genes XRCC1, XRCC3 and the level of chromosomal aberrations in the Uranium workers].

Association between the polymorphism of DNA repair genes XRCC1 Arg399ln and XRCC3 Thr241Met and the frequency of chromosomal aberrations in the uranium workers was studied. The Gln/Gln genotype of gene XRCC1 was associated with a significant increase in the number of chromosomal aberrations as compared to the corresponding homozygous wild type Arg/Arg (p < 0.05).

[Association of genetic polymorphism in GSTM1 and GSTT1 with the frequency of chromosomal aberrations in the uranium workers].

Association between genetic polymorphism in GSTM1 and GSTT1 and frequency of chromosomal aberrations in the workers occupationally exposed to uranium during 1-25 years in Tselinniy mining/milling complex in the North Kazakhstan was investigated. It was found that the frequency of chromosomal aberrations in uranium workers was significantly higher than in matched control, being correlated with the duration of exposure. No association between frequency of chromosomal aberrations and polymorphism for each gene (GSTM1 and GSTT1) was observed, whereas frequency of chromosomal aberrations in the homozygous carriers of null alleles of both GSTM1 and GSTT1 genes was higher than in the homozygous carriers of normal alleles.

[Changes in lower urinary tract function in children with hyperactive urinary bladder treated with combined therapy].

Low clinical efficacy of M-cholinolytics remains a serious problem in conservative therapy of hyperactive bladder (HB). To improve treatment outcomes, combined therapy (pikamilon plus driptan) was tried in 22 boys and 25 girls aged 7 to 14 years. The children were examined with uroflowmetry, cystometry.

[Diagnostic value of several immunity parameters in gestoses].

Gestosis is a grave complication of pregnancy. Assessment of its severity in various pregnancy terms is important for making decision about preterm delivery and predicting the outcome of pregnancy. The authors consider that such immunological tests as measurement of circulating immune complexes, NBT test, and cytological index of activity are reliable indicators of the severity of gestosis, which can be used for predicting the condition and its development.

[Changes of immunosorption properties in the blood and its components at various times after UV-irradiation].

Immunosorption activity in reference to antirhesus antibodies, of UV-irradiated Rh-positive preserved blood as well as of red blood cell pack and leucocytic-thrombocytic suspension prepared from this blood, was studied in varying terms after irradiation. The whole blood and red blood cell pack immunosorption activity significantly increased immediately after irradiation. The effect lasted during two days.