Publications by authors named "Z Tylichova"
Article Synopsis
- PD-L1 expression is a key factor in how cancer cells escape the immune system, and targeting the PD-L1/PD1 interaction is a common immunotherapy for melanoma patients, although many still do not respond.
- This study focused on different human melanoma cell lines with varying p53 status to examine the relationship between p53, PD-L1, and immune responses, using techniques like immunoblotting and flow cytometry.
- Results indicated that the loss of p53 impacts PD-L1 levels through the regulation of IRF1 and SOX10, and influences the ability of natural killer (NK) cells to kill tumor cells, highlighting the complex interplay of these factors in cancer immune response.
Article Synopsis
- TGFβ plays a significant role in inflammation, wound healing, and cancer, acting as a tumor suppressor in squamous cell carcinoma (SCC), which is linked to high ΔNp63 levels.
- Research shows that TGFβ selectively increases ΔNp63 protein in healthy cells via canonical signaling, but the relationship between mRNA levels and protein is complicated, showing initial increases followed by later declines.
- The interactions between TGFβ and p63 may affect epithelial-to-mesenchymal transition and influence tumor behavior and treatment responses in SCC.
The aryl hydrocarbon receptor (AhR) plays a wide range of physiological roles in cellular processes such as proliferation, migration or control of immune responses. Several studies have also indicated that AhR might contribute to the regulation of energy balance or cellular metabolism. We observed that the AhR is upregulated in tumor epithelial cells derived from colon cancer patients.
View Article and Find Full Text PDFApart from its role in the metabolism of carcinogens, the aryl hydrocarbon receptor (AhR) has been suggested to be involved in the control of inflammatory responses within the respiratory tract. However, the mechanisms responsible for this are only partially known. In this study, we used A549 cell line, as a human model of lung alveolar type II (ATII)-like cells, to study the functional role of the AhR in control of inflammatory responses.
View Article and Find Full Text PDFBackground: Hepatocellular carcinoma (HCC) is a major contributor to the worldwide cancer burden. Recent studies on HCC have demonstrated dramatic alterations in expression of several cytochrome P450 (CYP) family members that play a crucial role in biotransformation of many drugs and other xenobiotics; however, the mechanisms responsible for their deregulation remain unclear.
Methods: We investigated a potential involvement of miRNAs in downregulation of expression of CYPs observed in HCC tumors.