Publications by authors named "Z Tauber"
Inhibition of soluble epoxide hydrolase (sEH) appears to be promising for the treatment of many diseases. Studies have focused on the beneficial effects of epoxyeicosatrienoic acids (EETs), which are sEH substrates. However, our recent studies have shown that the sEH activity is crucial for the proper intestinal cell differentiation.
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- * In a 2021 study, researchers sequenced the viral metagenome of a Hyalomma marginatum tick and discovered the Volzhskoe tick virus, which is part of the unclassified Bunyaviricetes group.
- * The analysis revealed important genetic information and showed that the Volzhskoe tick virus is related to other unclassified species found in diverse locations, highlighting the need for more research on its potential health impacts and
Canine distemper virus (CDV) is a highly contagious virus that affects domestic and wild animals, causing severe illness with high mortality rates. Rapid monitoring and sequencing can provide valuable information about circulating CDV strains, which may foster effective vaccination strategies and the successful integration of these into conservation programs. During two site visits in Bangladesh in 2023, we tested a mobile, deployable genomic surveillance setup to explore the genetic diversity and phylogenetic patterns of locally circulating CDV strains.
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- Inflammation of the placenta can negatively impact both the fetus and the mother, with strong ties to diabetes during pregnancy.
- The study analyzed immune cell responses in the placenta from patients with type 1 diabetes mellitus (T1DM) and gestational diabetes mellitus (GDM), identifying differences in inflammatory markers and structural changes in the placental villi.
- Results indicated that T1DM is linked with increased inflammation in placental cells, while GDM shows stable inflammatory markers but significant issues with placental development, suggesting differing impacts of the two types of diabetes on placental health.
PTEN and soluble epoxide hydrolase in intestinal cell differentiation.
Biochim Biophys Acta Gen Subj
December 2023
Intestinal epithelial differentiation is a highly organised process. It is influenced by a variety of signalling pathways and enzymes, such as the PI3K pathway and soluble epoxide hydrolase (sEH) from arachidonic acid metabolism. We investigated the changes in the expression of enzymes and lipid messenger from the PI3K pathway, including PTEN, during intestinal cell differentiation in vitro using HT-29 and Caco2 cells and compared them with immunohistochemical patterns of these proteins in human colon.
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