Publications by authors named "Z Stylianidou"

Article Synopsis
  • Human myxovirus resistance 2 (MX2) inhibits HIV-1 and herpesviruses post-entry by interacting with viral capsids.
  • Researchers identified that MX2 interacts with numerous FG-rich proteins and forms multiprotein condensates essential for its antiviral activity.
  • These condensates trap the viral capsids and disrupt their entry into the nucleus, effectively preventing the viruses from delivering their genomes into host cells.
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West Nile virus (WNV) is an emerging neurotropic RNA virus and a member of the genus . Naturally, the virus is maintained in an enzootic cycle involving mosquitoes as vectors and birds that are the principal amplifying virus hosts. In humans, the incubation period for WNV disease ranges from 3 to 14 days, with an estimated 80% of infected persons being asymptomatic, around 19% developing a mild febrile infection and less than 1% developing neuroinvasive disease.

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Human noroviruses (HuNoVs) are the most common cause of viral gastroenteritis resulting annually in ~219,000 deaths and a societal cost of ~USD 60 billion, and no antivirals or vaccines are available. Here, we assess the anti-norovirus activity of new peptidomimetic aldehydes related to the protease inhibitor rupintrivir. The early hit compound inhibited the replication of murine norovirus (MNV) and the HuNoV GI.

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Purpose: The tumour suppressor protein RB plays a decisive role in negative control of the cell cycle, inhibiting tumour development. The present analysis investigated the prevalence of the nucleotide polymorphism A153104G, which is located at intron 18 of the RB1 gene, and investigated the impact of the polymorphic variability in the exon 19 and its flanking intronic sequences on the severity of cervical disease in HPV16-positive Greek women.

Methodology: The nucleotide polymorphism A153104G was detected by PCR-RFLP assay, while the amplicons were further subjected to cloning and sequencing.

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