Genome-wide association study identifying novel risk variants associated with glycaemic traits in the continental African AWI-Gen cohort.

Aims/hypothesis: Glycaemic traits such as high fasting glucose levels and insulin resistance are positively associated with the risk of type 2 diabetes and other cardiometabolic diseases. Genetic association studies have identified hundreds of associations for each glycaemic trait, yet very few studies have involved continental African populations. We report the results of genome-wide association studies (GWASs) in a pan-African cohort for four glycaemic traits, namely fasting glucose, fasting insulin, insulin resistance (HOMA-IR) and beta cell function (HOMA-B), which are quantitative variables that affect the risk of developing type 2 diabetes.

A Novel Differentiation Nomogram Model for Brucellar Spondylitis and Tuberculous Spondylitis.

Background: Tuberculous spondylitis (TS) and brucellar spondylitis (BS) exhibit certain similarities in clinical presentation and imaging characteristics, making differential diagnosis challenging. Developing a reliable differential diagnosis model can assist clinicians in distinguishing between these two conditions at an early stage, allowing for targeted prevention and treatment strategies.

Methods: Patients diagnosed with TS and BS were retrospectively collected and randomized into training and validation cohorts (ratio 7:3).

Dynamic evaluation and prediction of the ecological environment quality of the urban agglomeration on the northern slope of Tianshan Mountains.

In order to timely determine the dynamic changes of the ecological environment quality and future development laws of the urban agglomeration on the northern slope of the Tianshan Mountains, combined with the actual situation of the urban agglomeration, 11 indicators were selected from the three aspects of natural ecology, social ecology, and economic ecology. To reduce the dimensions of the indicators, principal component analysis, coefficient of variation, and analytic hierarchy process were used based on RS and GIS technology methods, and the ecological environmental quality (EQI) from 2000 to 2018 was dynamically evaluated. Further, the CA-Markov model was introduced to simulate the development status in 2026 for predictive purposes.

Study of coordinated development of county urbanization in arid areas of China: The case of Xinjiang.

Urbanization is a comprehensive process of mutual influence among the population, economy, society and living environment, and it depends on the synergy of a series of factors. This paper uses the statistical data of 76 counties in Xinjiang from 1996 to 2018 to construct a comprehensive urbanization evaluation system. Based on the entropy method, comprehensive evaluation model and coupling coordination model, from the scales of time and space, this paper discusses the current situation of the coordinated development of population, economy, society and living environment factors in counties in Xinjiang in the process of urbanization.

Spatial Pattern Analysis of Xinjiang Tourism Resources Based on Electronic Map Points of Interest.

This study considers the Point of Interest data of tourism resources in Xinjiang and studies their spatial distribution by combining geospatial analysis methods, such as the average nearest neighbor index, standard deviation ellipse, kernel density analysis, and hotspot analysis, to explore their spatial distribution characteristics. Based on the analysis results, the following conclusions are made. Different categories of tourism resource sites have different spatial distributions, and all categories of tourism resources in Xinjiang are clustered in Urumqi city.