Comparison of baseline global gene expression profiles of prostate cancer cell lines LNCaP and DU145.

Introduction: DU145 and LNCaP are classic prostate cancer cell lines. Characterizing their baseline transcriptomics profiles (without any intervention) can offer insights into baseline genetic features and oncogenic pathways that should be considered while interpreting findings after various experimental interventions such as exogenous gene transfection or drug treatment.

Methods: LNCaP and DU145 cell lines were cultured under normal conditions, followed by RNA extraction, cDNA conversion, library preparation, and RNA sequencing using the Illumina NovaSeq platform.

Double-Edge Effects of Leucine on Cancer Cells.

Leucine is an essential amino acid that cannot be produced endogenously in the human body and therefore needs to be obtained from dietary sources. Leucine plays a pivotal role in stimulating muscle protein synthesis, along with isoleucine and valine, as the group of branched-chain amino acids, making them one of the most popular dietary supplements for athletes and gym-goers. The individual effects of leucine, however, have not been fully clarified, as most of the studies so far have focused on the grouped effects of branched-chain amino acids.

Reassortants of the Highly Pathogenic Influenza Virus A/H5N1 Causing Mass Swan Mortality in Kazakhstan from 2023 to 2024.

In the winter of 2023/2024, the mass death of swans was observed on Lake Karakol on the eastern coast of the Caspian Sea. From 21 December 2023 to 25 January 2024, 1132 swan corpses (, ) were collected and disposed of on the coast by veterinary services and ecologists. Biological samples were collected from 18 birds for analysis at different dates of the epizootic.

Carbon nanoparticles neutralize carbon dioxide (CO) in cytotoxicity: Potent carbon emission induced resistance to anticancer nanomedicine and antibiotics.

Excessive carbon emissions, especially CO release, have been a global concern. Few studies applied nanotechnology to relieve the ecotoxicity of CO. Here, we applied carbon dots (CDs) to neutralize the CO.

IR Spectroscopic Degradation Study of Thin Organometal Halide Perovskite Films.

The advantages of IR spectroscopy include relatively fast analysis and sensitivity, which facilitate its wide application in the pharmaceutical, chemical and polymer sectors. Thus, IR spectroscopy provides an excellent opportunity to monitor the degradation and concomitant evolution of the molecular structure within a perovskite layer. As is well-known, one of the main limitations preventing the industrialization of perovskite solar cells is the relatively low resistance to various degradation factors.