Participation of coenzyme Q10 in the rejection development of the transplanted heart: a clinical study.

Coenzyme Q10 and alpha-tocopherol concentrations were assessed in 28 endomyocardial biopsies from 22 patients and in 61 blood samples from 31 patients after heart transplantation with histologically confirmed signs of rejection. The values were compared to the group of 14 patients with cardiomyopathies of unclear etiology as candidates for heart transplantation. Blood analyses were also compared with 50 healthy persons.

Coenzyme Q10 depletion and mitochondrial energy disturbances in rejection development in patients after heart transplantation.

Unlabelled: Sixty endomyocardial biopsies (EMB) and whole blood or plasma samples from 34 patients after heart transplantation (HTx-pts) were studied. Acute rejection of the transplanted heart was histologically graded as: 0 (without), 0-1 (incipient), 1 (mild), 2 (moderate). The level of coenzyme Q10 (CoQ10) in 28 EMB was estimated by HPLC.

[Diagnosis and therapy of acute rejection in patients after orthotopic heart transplantation].

Objective: In organ allotransplantation represents a serious problem acute rejection, which is the reaction of recipient organism aimed to reject the transplanted organ.

Aim: To obtain experience in the field of routine long term are of patients after heart transplantation living in Slovakia.

Method: 33 patients after orthotopic heart transplantation (HTx) were included in our long term care by the 1.

[Hyperlipoproteinemia in patients after heart transplantation].

Hyperlipidaemia is one of the most frequent metabolic disorders after heart transplantation (HTx). The significance of hyperlipidaemia is stressed mainly in relation to graft vascular disease (GVD) which is the leading cause of death more than one year after transplantation. Recently the evidence on the role of hyperlipidaemia (HLP) in the pathogenesis of GVD is growing.

[Preparation for heart transplantation in Slovakia 1994-1997].

The authors present the process of introduction heart transplant programme in the years 1994-1997 in Slovakia. A short historical review about heart transplantation is given in the article. Fundamental requirements for heart transplantation realization, activities of Working group "Heart transplantation", methods of follow-up of patients after heart transplantation and selection of candidates for transplantation, are discussed.