Publications by authors named "Z Samoon"
Article Synopsis
- The study focused on the occurrence of febrile neutropenia (FN) in patients with intermediate risk while undergoing chemotherapy, aiming to better understand its incidence.
- The research involved 364 patients with solid tumors or lymphomas, tracking them through multiple cycles of chemotherapy; FN rates were highest during the first cycle.
- Findings indicated a low overall FN incidence, especially after the first cycle, suggesting that, based on clinician discretion, prophylactic use of granulocyte colony-stimulating factor (G-CSF) might be beneficial for these patients.
Background: Liquid biopsy (LB) analysis using (ctDNA)/cell-free DNA (cfDNA) is an emerging alternative to tissue profiling in (NSCLC). LB is used to guide treatment decisions, detect resistance mechanisms, and predicts responses, and, therefore, outcomes. This systematic review and meta-analysis evaluated the impact of LB quantification on clinical outcomes in molecularly altered advanced NSCLC undergoing targeted therapies.
View Article and Find Full Text PDFBackground: AGITG DOCTOR was a randomised phase 2 trial of pre-operative cisplatin, 5 fluorouracil (CF) followed by docetaxel (D) with or without radiotherapy (RT) based on poor early response to CF, detected via PET, for resectable oesophageal adenocarcinoma. This study describes PROs over 2 years.
Methods: Participants (N = 116) completed the EORTC QLQ-C30 and oesophageal module (QLQ-OES18) before chemotherapy (baseline), before surgery, six and 12 weeks post-surgery and three-monthly until 2 years.
Chemotherapy in resectable or potentially resectable colon cancer with liver metastases.
Expert Opin Pharmacother
April 2022
Introduction: The treatment of colorectal cancer liver metastases has seen significant improvement in recent years and, for certain patients, the long-term survival and even cure are possible. Despite this improvement, many more questions are yet to be answered: the optimal combination, duration, sequence of therapies, role of biologics and the timing of surgical resection are debated in the literature, with conflicting trial results.
Areas Covered: In this review, the authors highlight the current trial evidence for systemic chemotherapy and biologic therapy for colorectal cancer liver metastases in both the pre and post-resection setting.