Publications by authors named "Z Sachetto"
Cardiovascular safety of the class of JAK inhibitors or tocilizumab compared with TNF inhibitors in patients with rheumatoid arthritis: Systematic review and a traditional and Bayesian network meta-analysis of randomized clinical trials.
Alisson Pugliesi Daniela Gomes Chicre Oliveira Vani Abreu de Souza Filho Júlia de Oliveira Machado Aline Gonçalves Pereira Zoraida Sachetto
Semin Arthritis Rheum
December 2024
Article Synopsis
- The study compared the risks of major adverse cardiovascular events (MACE) and all-cause death (ACD) in rheumatoid arthritis patients treated with JAK inhibitors (JAKi) or tocilizumab (TCZ) versus tumor necrosis factor inhibitors (TNFi).
- A systematic review of randomized controlled trials showed that JAKi were associated with a non-significant increase in risks for MACE and ACD compared to TNFi, with Bayesian analysis indicating a higher probability of these events occurring with JAKi.
- The analysis highlighted the need for more data, particularly on JAKi other than tofacitinib, to make informed regulatory recommendations regarding their use.
Article Synopsis
- Depression and anxiety are common issues faced by Behçet's disease (BD) patients in Brazil, affecting their quality of life (HRQoL) and management of their condition.
- A study involving 58 BD patients and 96 healthy controls showed high levels of depression and anxiety linked to factors such as younger age, lack of a partner, shorter disease duration, and lower income.
- The findings indicate that BD patients experience significant restrictions in HRQoL, especially in physical and emotional aspects, highlighting the need for increased focus on mental health in their treatment.
Trousseau Syndrome (TS) is defined as the occurrence of thromboembolic events prior to or simultaneously with the diagnosis of visceral neoplasia. In cases of multiple thromboembolisms, considering the possibility of TS, a screening for neoplasms may be warranted. We present a case study of a 61-year-old female who presented a neurological deficit.
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- The study aimed to evaluate foot function in patients with Systemic Sclerosis (SSc) and how it relates to various sociodemographic and clinical factors, assessing aspects like mobility, foot pain, and foot care.
- Among 101 SSc patients, over half experienced forefoot pain, around one-third had hindfoot pain, and many had other foot issues such as ulcers and callosities; foot function and pain levels correlated with the severity of symptoms related to SSc.
- The findings highlighted a significant prevalence of foot dysfunction in SSc patients, underlining the need for better foot care and routine examinations in clinical practice to address these issues effectively.