Autolysosomes in Alzheimer's disease and their possible role in its pathogenesis. An ultrastructural study.

In 10 cases of senile dementia of Alzheimer's type (AD) a systematic post-mortem ultrastructural analysis was performed. Attention was paid mainly to the presence of autolysosomes in the neuropil of the brain cortex. Autolysosomes appeared as osmiophilic dense bodies (DB) which originated in synaptic terminals and peripheral nerve-cell processes.

[Morphological changes in the brain in schizophrenia].

In 1975-1985 in the mental hospital in Dobrany died 225 patients with chronic schizophrenia. The author presents the causes of death confirmed by necropsy. In all the brain was examined by a light microscope.

Ultrastructure of cortical synapses in the brain of schizophrenics.

The autopsy was performed in 225 cases of chronic schizophrenia. In 44 cases examination of the brain by light microscope revealed changes typical of Alzheimer's disease. The increased risk for the development of Alzheimer's disease in chronic schizophrenia is pointed out.