Cardioprotective conditioning with glucose and insulin prior to cardiac surgery involving ischaemic cold arrest.

The study describes cardioprotective conditioning by means of high doses of glucose together with insulin and potassium. Eighteen hours before cardiac surgery, nine patients received continuous infusion of 1000 ml of 40% glucose solution along with 112 U of insulin and 60 mmol of potassium. Before and after ischaemic cold arrest, the myocardial a--v differences of lactate, pyruvate, glucose, Na, K, Cl, Ca, P, free fatty acids and triglycerides were analysed in all patients.

Results of intensified insulin therapy in type-I diabetics receiving instruction in self-monitoring.

Therapeutic success in I-Type diabetes (i.e., glycaemia close to normal levels in an effort to influence favourably the onset and progression of long-term complications), two important preconditions must be met.