New Polyhydroxysteroids Derivatives from Starfish Asterias amurensis Induce Embryotoxicity in Marine Medaka.

In recent years, multiple population outbreaks of the Northern Pacific starfish (Asterias amurensis) have been documented off the coast of Qingdao. Starfish use chemosensation to regulate their life history and interactions with the environment, with their secondary metabolites serving as deterrents and dispersal agents against predators. While the eggs of marine fish are passive and susceptible, we hypothesized that the secondary metabolites of A.

Molecular Chain Interpenetration-Enabled High Interfacial Compatibility of Ionic and Electronic Conductors for Stretchable Ionic Devices.

Ionic devices find applications such as flexible electronics and biomedicines and function by exploiting hybrid circuits of mobile ions and electrons. However, the poor interfacial compatibility of hard electronic conductors with soft ionic conductors in ionic devices leads to low deformability, sensitivity, electromechanical responses, and stability. Herein, an interpenetrating interface between silicone-modified polyurethane/carbon nanotube electronic conductors and ionoelastomers in an ionic device using in situ polymerization is fabricated.

Multiple Intra-Articular Injections of Adipose-Derived Mesenchymal Stem Cells for Canine Osteoarthritis Treatment.

Osteoarthritis (OA) is one of the most common degenerative diseases in dogs and humans, which can lead to articular cartilage deterioration, chronic pain, and decreased quality of life. The anti-inflammatory, anti-fibrotic, analgesic, and cartilage regeneration properties of mesenchymal stem cell (MSC) therapy provide a new direction for the treatment development of OA in the future. Currently, MSC therapy lacks confirmed ideal sources, dosages, formulations, and specific characteristics.

Effect of acupuncture in patients with postprandial distress syndrome: study protocol for a randomized controlled trial.

Background: Postprandial distress syndrome (PDS) is the prominent subtype in patients with functional dyspepsia (FD) and currently lacks a satisfactory treatment. Acupuncture has become a promising alternative and complementary therapy for managing FD. However, high-level clinical evidence supporting the use of acupuncture for FD is limited.

Therapeutic potential of total flavonoids of Rhizoma Drynariae: inhibiting adipogenesis and promoting osteogenesis via MAPK/HIF-1α pathway in primary osteoporosis.

Aim: This study seeks to confirm the therapeutic effectiveness of TRFD in inhibiting adipogenesis and promoting osteogenesis in primary osteoporosis through the MAPK/HIF-1α signaling pathway. C57BL/6J mice underwent ovariectomy (OVX) to induce osteoporosis. Mice were administered TRFD (Low and high doses)estradiol for a duration of 12 weeks.