Publications by authors named "Z S Saifi"

Antibiotic-resistant bacteria are a serious global health threat, making infections harder to treat and increasing medical costs and mortality rates. To combat resistant bacterial strains, a series of compounds (QS1-12) were synthesized with an excellent yield of 85-92%. Initial assessments of these analogues as potential antibacterial agents were conducted through a preliminary screening against a panel of diverse bacterial strains.

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Non-alcoholic fatty liver disease (NAFLD) is a significant consequence of metabolic dysfunction, often associated with changes in the intestinal microbiota. Prebiotics and probiotics have shown promise in NAFLD management. This study evaluated a silymarin-based herbal remedy with piperine and fulvic acid, alongside a probiotic blend of , , and .

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Bacteria employ quorum sensing as a remarkable mechanism for coordinating behaviors and communicating within their communities. In this study, we introduce a MATLAB Graphical User Interface (GUI) that offers a versatile platform for exploring the dynamics of quorum sensing. Our computational framework allows for the assessment of quorum sensing, the investigation of parameter dependencies, and the prediction of minimum biofilm thickness required for its initiation.

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Article Synopsis
  • Risedronate sodium (RIS) faces challenges like low bioavailability and gastrointestinal side effects when taken orally, prompting the creation of mPEG-coated nanoparticles loaded with RIS-HA-TCS for osteoporosis treatment.
  • Characterization of the nanoparticles showed a good drug entrapment efficiency of 85.4% and optimal particle size (252.1 nm), indicating effective formulation through the ionic gelation process.
  • In vitro and ex vivo studies revealed that the mPEG-coated nanoparticles provide superior drug release and gut permeability compared to conventional RIS formulations, suggesting a promising alternative delivery method.
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Risedronate-loaded mPEG-coated hydroxyapatite, thiolated chitosan-based (coated) and non-coated nanoparticles were tested for their potential effects in the treatment of osteoporosis. The prepared nanoparticles were evaluated for their bone-targeting potential by inducing osteoporosis in female Wistar rats via oral administration of Dexona (dexamethasone sodium phosphate). In vivo pharmacokinetic and pharmacodynamic studies were performed on osteoporotic rat models treated with different formulations.

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