[Interactions between herbicides and various of the most frequently used drug groups. I. Interactions between chronically administered herbicides: carbendazyme, 2,4-dichlorophenoxyacetic acid and 2,4,5-trichlorophenoxyacetic acid and drugs affecting the circulatory system].

The influence of chronically administered (6 weeks) herbicides (KAR, 2,4-D and 2,4,5-T) on pharmacological effects of quinidine, reserpine and strophantin K in mice and rats was examined in vivo. The investigated herbicides produced in mice an increase in acute toxicity of strophantin K, the acute toxicity of either reserpine oro quinidine being unchanged. The herbicides alone, after 6 weeks administration, significantly increased mean arterial pressure of rats, however the hypotensive response to reserpine was not statistically influenced in these animals as compared with controls.