Immune reactions in patients with type I and with type II diabetes mellitus.

Since several data refer to the role of immune processes in the pathogenesis of diabetes mellitus, this study was performed to compare aspecific and specific immune reactions in type I- and in type II diabetic patients over a six month period. The percentage and the absolute number of SRBC-rosette forming active E(A), of theophylline-resistant E(Thr) and of ORCB-rosette forming T(M)-cell subsets proved to be elevated in newly diagnosed type I but reduced in type II diabetic patients. Also an elevated percentage of HLA-DR positive, activated T cells was found in the majority of recent-onset type I diabetics.

T-lymphocyte subsets and their cytotoxic capacity in patients with type I and type II diabetes mellitus.

Distribution and cytotoxic function of lymphocyte subpopulations were studied in 20 patients with type I, in 20 patients with type II diabetes mellitus and in 40 control subjects. The percentage, the absolute number of (EA), (E Thr), (TM) subsets and the rate of (E Thr) (E Ths) and (TM/) (TG) cells were found to be higher in type I and lower in type II diabetic patients than in controls. This opposite tendency in the distribution of T-lymphocyte subsets may be related to the duration of diabetes.

[Antibody-dependent cytotoxicity capacity of healthy women and men in old age].

The authors studied the ADCC capacity in 42 healthy aged persons. The Bakács-Garam Test were used. The allogen and the xenogen systems were investigated, with the mentioned methods.