The effect of formoterol over 24 h in patients with asthma: the role of enantiomers.

The single-dose effect of formoterol racemate and enantiomers on bronchodilatation up to 24 h was determined. Forty-six reversible asthmatic patients were randomised to this double blind, crossover study. Formoterol was inhaled by nebulizer (HaloLite); 4.

Assessment of a relative therapeutic index between inhaled formoterol and salbuterol in asthma patients.

Objective: To quantify the relation between local and systemic magnitudes of effects of inhaled formoterol and salbutamol.

Methods: Twenty-eight stable asthmatic patients completed this double-blind, randomised crossover study. Pre-drug administration FEV1 (mean 2.

Relative therapeutic index between inhaled formoterol and salbutamol in asthma patients.

A double-blind, randomized crossover study in 28 asthmatic patients assessed the relative therapeutic index for inhaled formoterol and salbutamol. Pre-drug administration FEV1 (mean 2.08 l) was 49-93% of predicted and reversibility 16-82% after inhalation of salbutamol.