Monolithically integrated solid-state vertical organic electrochemical transistors switching between neuromorphic and logic functions.

Manipulating the ionic-electronic coupling in organic electrochemical transistors (OECTs) offers opportunities for interesting phenomena and advanced applications but has not been systematically exploited. Here, we develop monolithically integrated solid-state vertical OECTs to fully explore polyelectrolyte's strengths, enabling the OECTs to switch between neuromorphic and logic functions. This transition capability is achieved by mastering the complex transport of large-size polycations within the channel through well-designed drain electrodes.

All-fiber three-wavelength laser for functional photoacoustic microscopy.

Advanced multi-wavelength pulsed laser is a key technique for functional optical-resolution photoacoustic microscopy (OR-PAM). By utilizing the stimulated Raman scattering (SRS) effect, we can generate various wavelengths from a single-wavelength pump laser, offering a simple and cost-effective solution for OR-PAM. However, existing multi-wavelength SRS lasers typically require fine alignment of many free-space optical components with single-mode fibers, which are susceptible to mechanical disturbances and temperature fluctuations, leading to high maintenance costs.

The immunomodulation of outer membrane vesicles from Vibrio parahaemolyticus causing acute hepatopancreatic necrosis disease (VpAHPND) in Pacific white shrimp Litopenaeus vannamei.

Vibrio parahaemolyticus causing acute hepatopancreatic necrosis disease (VpAHPND) is a significant bacterial pathogen to Litopenaeus vannamei aquaculture with a substantial economic burden. Outer membrane vesicles (OMVs) released by Gram-negative pathogenic bacteria play complex roles in the modulation on host's immune response. To elucidate the potential roles of VpAHPND-OMVs on L.

Structure-based molecular hybridization design and synthesis of Keap1-Nrf2 inhibitors for anti-inflammatory treatment.

The Kelch-like ECH-associated protein 1 (Keap1)-nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway stands as a pivotal mechanism in defending against oxidative stress damage and related inflammation. Blocking the Keap1-Nrf2 protein-protein interaction (PPI) offers a promising therapeutic approach for treating diseases related to oxidative stress and inflammation. Our group previously reported NXPZ-2, a naphthalene sulfonamide derivative targeting Keap1, which effectively inhibits the Keap1-Nrf2 PPI, thereby releasing Nrf2 to exert its anti-inflammatory and antioxidant effects.