Publications by authors named "Z Qing"
Alkaline phosphatase (ALP) is a critical biomarker associated with various physiological and pathological processes, making its detection essential for disease diagnosis and biomedical research. In this study, we developed a novel, simple, and portable visual quantification method for ALP activity in cells using an efficient CuZnS nanomaterial with peroxidase-like properties, integrated into a smartphone-based platform for enhanced usability. The CuZnS nanomaterial catalyzes the breakdown of H₂O₂, generating ·OH radicals that oxidize the colorless substrate TMB into blue oxTMB, which is subsequently reduced back to TMB by ascorbic acid (AA).
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- Enzymes are typically used in biosensing for signal amplification, but their performance can vary with changes in the environment, like pH and temperature.
- The new approach, called activity-independent enzyme-powered (AIEP) amplification, aims to stabilize and improve signal quality without relying on enzyme activity during the biosensing process.
- The method was tested by monitoring oxidative stress in drug-induced liver injury, showing that it effectively evaluates hepatoprotective effects using a specific fluorophore and a degradation-triggered nanobeacon.
Article Synopsis
- - This study investigated how family dynamics impact altruism in adolescents, looking specifically at the roles of extraversion and social support as mediating factors.
- - Surveys were distributed to 972 high school students in Guangdong Province, using established questionnaires to assess family function, personality traits, social support, and altruistic behavior.
- - Results showed that family function alone does not predict altruistic behavior; instead, extraverted personality and perceived social support serve as crucial mediators, indicating the need for positive family environments to encourage altruistic actions.
Article Synopsis
- The study focuses on cognitive frailty (CF), which is when older adults experience both physical weakness and cognitive decline without having Alzheimer's or other dementias, specifically looking at its prevalence in Chinese seniors.
- After analyzing 56 studies with over 80,000 participants, the prevalence of various CF types ranged from 14.3% in community dwellers to 25.2% in older inpatients, highlighting a significant public health concern.
- Key factors influencing CF included age, gender, education, nutrition, mental health, physical activity, sleep quality, and existing medical conditions, emphasizing the importance of promoting healthy lifestyle choices to combat CF.
Unlabelled: Colorectal cancer (CRC) is a common tumor type, and liver metastasis reduces the long-term survival in CRC patients. Natural killer (NK) cells play an important role in anti-tumor immunity. The aim of this study was to investigate the mechanism of miR-214-5p on NK cells in CRC liver metastasis.
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