Urinary bioorthogonal reporters for the monitoring of the efficacy of chemotherapy for lung cancer and of associated kidney injury.

The utility of urinary tests for the monitoring of the treatment efficacy and adverse events of anticancer therapies is constrained by the low concentration of relevant urinary biomarkers. Here we report, using mice with lung cancer and treated with chemotherapy, of a urinary fluorescence test for the concurrent monitoring of the levels of a tumour biomarker (cathepsin B) and of a biomarker of chemotherapy-induced kidney injury (N-acetyl-β-D-glucosaminidase). The test involves two intratracheally administered urinary reporters leveraging caged bioorthogonal click handles for the biomarker-dependent activation of 'clickability' and renal clearance, and the bioorthogonal click reaction of each renally cleared reporter with paired fluorescence indicators in the collected urine.

Genome sequence of ZAPR22R, isolated from calla lily in China.

Here, we present the complete genome sequence of strain ZAPR22R, isolated from the petiole and tuber of calla lily (), infected with soft rot. The genome consists of a single chromosome (4,528,722 bp) with a G+C content of 41.1%.

Association between body esteem and sugar-sweetened beverage intake among Chinese undergraduate students: a cross-sectional study.

Background: High intake of sugar-sweetened beverages has been linked to a range of physical, psychological, and emotional issues. Although there were various factors influencing sugar-sweetened beverage intake, the relationship between body esteem and sugar-sweetened beverage intake remains unclear. This study aimed to investigate the association between three dimensions of body esteem (body esteem-appearance, body esteem-attribution, and body esteem-weight) and the likelihood of high sugar-sweetened beverage intake.

Risk Factors of Delirium Following Reconstructive Surgery for Head and Neck Tumors: A Retrospective Clinical Trial.

Background: Patients after head and neck tumor reconstruction surgery frequently require deep sedation and analgesia in the ICU. However, the risk factors for delirium associated with propofol-based sedation remain unclear.

Objective: The study aimed to explore the risk factors of delirium of propofol singled or combined sedation.

THz-induced gas alignment in dispersionless field enhancing waveguides.

We demonstrate a versatile THz waveguide platform for tailored THz-induced orientation and alignment of gas molecules. The underlying waveguide structure is dispersionless, with a refractive index close to one, and enhances the electric as well as the magnetic field up to a factor of five. These properties increase the detected transient birefringence signal by more than an order of magnitude compared to conventional THz free space focusing.