Lack of an association between apolipoprotein B XbaI polymorphism and blood lipid parameters in childhood.

The frequencies of the alleles of XbaI polymorphism in the apolipoprotein B gene were determined in two groups of children, 82 with high (HCG) and 86 with low (LCG) cholesterol levels. A slightly higher incidence of the X2X2 genotype in HCG was found, but the differences were not statistically significant. No relations were found between the XbaI polymorphic site and the levels of serum lipids and lipoproteins.

[Decrease in cardiovascular disease mortality in the Czech Republic from 1984 to 1993 and its possible causes].

Background: The objective of the investigation was to evaluate the ten-year development of the cardiovascular mortality rate in two population groups in the age bracket from 25 to 64 years, i.e. in subjects living in six districts which participated in the international WHO project MONICA and in the population of the whole Czech Republic.

Political changes and trends in cardiovascular risk factors in the Czech Republic, 1985-92.

Background: Mortality from cardiovascular diseases is substantially higher in central and eastern Europe than in the west. After the fall of communism, these countries have undergone radical changes in their political, social, and economic environments but little is known about the impact of these changes on health behaviours or risk factors. Data from the Czech Republic, a country whose mortality rates from cardiovascular diseases are among the highest, were analysed in this report.

[Is the recent decrease in cholesterolemia in the Czech Republic convincing evidence?].

Background: The objective of the study was to evaluate the 8-year trend of serum cholesterol levels in six districts of the Czech Republic, to assess whether the reduction of mean values of total cholesterol recorded during the period between 1985 and 1992 was convincing and to discuss possible causes and consequences of this development.

Methods And Results: Three cross-sectional surveys of risk factors were implemented in independent random 1% samples of the population aged 25-64 years. In 1985 1256 men (respondence rate 81.

[Relation between educational level and prevalence of cardiovascular risk factors].

Background: Although socioeconomic factors are significant predictors of cardiovascular disease risk, their role has not yet been fully elucidated in our country. The objective of the present work was to find out whether they participate, and to what extent, in cardiovascular diseases.

Methods And Results: We re-analyzed data assembled during the second cross-sectional survey of the MONICA project in 1988: the investigated population, comprising 1349 men and 1407 women, was divided into four age groups (25-34, 35-44, 45-54 and 55-64 years) and into three groups by the highest achieved education (elementary, secondary and university).