Publications by authors named "Z Pavai"
Introduction: The kidney develops from two mesodermal primordia. Aquaporin 1 (AQP1) is a membrane protein characteristic to epithelial and endothelial cell of the human body. The Pax family of genes encodes transcription factors with important role in intrauterine development.
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- The study focuses on identifying EGFR gene mutations in lung adenocarcinoma patients to improve the selection process for tyrosine-kinase inhibitor therapy.
- Utilizing allele-specific PCR, researchers examined both formalin-fixed paraffin-embedded (FFPE) and fresh tissue samples to pinpoint specific mutations (deletions in exon 19 and point mutations in exon 21).
- However, issues with DNA fragmentation in FFPE samples hindered mutation detection, highlighting the need for standardized sample processing methods to enhance molecular testing accuracy.
Unlabelled: The balance between apoptosis and proliferation is tipped towards a decrease of apoptosis as the colonocyte progresses in the adenoma to carcinoma sequence of colon carcinogenesis. According to literature data, proteins like p53, Ki-67, APAF-1, Ets-1, PTEN contribute to inhibition of apoptosis and stimulation of proliferation.
Aim: Considering the complex interference among colorectal carcinogenetic mechanisms, our aim was to study the markers Ets-1 and APAF-1 relative to p53, Ki-67 and PTEN expression in colon adenomas/polyps (A/P).
There is a great need for living valve replacements for patients of all ages. Such constructs could be built by tissue engineering, with perspective of the unique structure and biology of the aortic root. The aortic valve root is composed of several different tissues, and careful structural and functional consideration has to be given to each segment and component.
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- The study investigates how simvastatins and fenofibrates affect the femur bones of ovariectomized and non-ovariectomized Wistar albino rats using 1D 1H-NMR T2-distribution methods.
- A total of 72 rats were divided into six groups and were analyzed at different time intervals after ovariectomy, with bone samples collected for analysis of moisture and pore distribution.
- Results indicated that the effects of the drugs on bone structure varied significantly with treatment duration, emphasizing that treating healthy bones with these lipid-lowering medications is generally not advisable.