[Results of two year use of dipyridamole and metindol in patients with primary focal and (or) segmental glomerulosclerosis].

Primary focal or segmental glomerulosclerosis is neuropathy diagnosed in 10% of children and 20% of adult patients with nephrotic syndrome. Immunosuppressive therapy was applied during two years period. The very good clinical results were obtained in 20% and good results in 40% of patients after indomethacin and dipyridamole therapy.

[The role of cellular immunity in the pathogenesis of glomerulonephritis].

In this article, experimental data and clinical observations suggesting the role of cell-mediated immunity in pathogenesis of primary glomerulonephritis have been presented. Serum anti-GBM antibodies have been observed in glomerulopathies mediated by anti-glomerular basement membrane antibodies with the presence of immunoglobulins in glomeruli and in their eluates. The lymphocytes from patients with glomerular disease show cell-mediated immune reactivity against GBM antigens.