[The first experience of using sevorane in the Ikrutsk Cardiosurgical Center].

An anesthetic mode used during operations under extracorporeal circulation was comparatively analyzed in children operated on for congenital heart diseases. The preference of inhalational anesthesia using the anesthetic sevorane was revealed. The use of the anesthetic reduced the need for opioid analgesics and activated patients in the early postoperative period.

[Biochemical characteristics of the brain mediator systems during stimulation of metastasis from surgical removal of a tumor].

In cases of tumor surgical operation, which stimulated metastatic spreading, distinct activation of hypothalamic structures was observed simultaneously with generalization of impairments in the neurotransmitting systems, accompanied by their exhaustion and disturbance. Pathology-related alterations in brain neurotransmitting reactions, provoked by surgical operation in cases of tumors, considerably exceeded similar parameters in non-operated or sham-operated animals.

[The effect of Leu- and Met-enkephalins on the adenosine deaminase and 5'-nucleotidase activities of the lymphocytes under conditions of stress stimulation of metastasis].

A correlation between changes of the hypothalamic mediator processes, hormone level in blood plasma, catecholamines and their catabolites in urine and changes of the activity of adenosine metabolism enzymes in the thymus and the spleen lymphocytes has been observed in C57B1 mice with Lewis lung carcinoma. Effect of leu- and met-enkephalines on neuroendocrine stress-realizing mechanisms proved to be different, that is responsible for their contrary effect on the metastatic growth--leu-enkephaline inhibits and met-enkephaline stimulates the process. It has been shown that an inhibitory effect of leu-enkephaline is greatly related to its stimulating influence on the thymus lymphocyte activity and a decrease of the functional activity of the spleen lymphocytes.