Publications by authors named "Z Nedelska"
Article Synopsis
- Cardiorespiratory signals, previously considered noise in fMRI research, are now recognized for their potential insights into brain function and health.
- These signals, including heart rate variability and respiratory patterns, reflect the interaction between cardiovascular, respiratory, and neural systems that support brain activity.
- Understanding these signals can improve fMRI data interpretation, highlighting the connections between heart, brain, and overall physiological health.
Impaired spatial navigation is early marker of Alzheimer's disease (AD). We examined ability of self- and informant-reported navigation questionnaires to discriminate between clinically and biomarker-defined participants, and associations of questionnaires with navigation performance, regional brain atrophy, AD biomarkers, and biomarker status. 262 participants (cognitively normal, with subjective cognitive decline, amnestic mild cognitive impairment [aMCI], and mild dementia) and their informants completed three navigation questionnaires.
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- This study investigates mitophagy impairment in Alzheimer's disease (AD) by examining biomarkers in serum and cerebrospinal fluid (CSF) from 246 individuals, including those with mild cognitive impairment (MCI-AD), AD dementia, and cognitively unimpaired individuals.
- The results indicate that certain biomarkers (PINK1, BNIP3L, TFEB) were differently expressed in individuals with AD compared to those who were cognitively unimpaired, suggesting a link between mitophagy impairment and AD pathology.
- Moreover, the levels of these biomarkers correlated with cognitive function and clinical indicators of AD severity, highlighting the potential of mitophagy biomarkers as indicators for disease progression.
Introduction: Sex influences neurodegeneration, but it has been poorly investigated in dementia with Lewy bodies (DLB). We investigated sex differences in brain atrophy in DLB using magnetic resonance imaging (MRI).
Methods: We included 436 patients from the European-DLB consortium and the Mayo Clinic.
Background: There is a need to better understand the rate of cognitive and motor decline of Dementia with Lewy bodies (DLB) and Parkinson's disease Dementia (PDD).
Objectives: To compare the rate of cognitive and motor decline in patients with DLB and PDD from the E-DLB Consortium and the Parkinson's Incidence Cohorts Collaboration (PICC) Cohorts.
Methods: The annual change in MMSE and MDS-UPDRS part III was estimated using linear mixed regression models in patients with at least one follow-up (DLB = 837 and PDD = 157).