Publications by authors named "Z Nazir"

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have been developed to manage type 2 diabetes mellitus. Although, in the last 10 years, the use of GLP-1 RAs, especially semaglutide and liraglutide, has increased, its clinical implications and how it affects metabolic parameters have yet to be fully consolidated. This narrative review explores the metabolic effects of GLP-1 RAs in weight management, blood glucose, cardiovascular health, lipid profiles, and blood pressure.

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Shock is a state of inadequate perfusion that affects vital organs. Cardiogenic shock (CS) predisposes patients to various arrhythmias. The adverse effect depends on intervention and pharmacogenomics.

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Objective: To explore the impact of perioperative intravenous (IV) paracetamol, administered with caudal ropivacaine on the quality of postoperative recovery in children undergoing hypospadias repair.

Study Design: Double-blinded randomised controlled trial. Place and Duration of the Study: The operating room, post-anaesthesia care unit (PACU), and paediatric surgical ward at the Aga Khan University Hospital, from 31st January 2019 to 1st May 2022.

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Bowel obstruction is a common complication that can affect patients due to different factors, including after a history of gastric bypass surgery. This review was conducted by searching the literature using both PubMed and Google Scholar for articles relating to bowel obstructions. Fifty-six articles were found after applying inclusion and exclusion criteria.

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Article Synopsis
  • * The text highlights the impact of opioids on fetal brain development, discussing how they disrupt important processes like synaptic plasticity and myelination, which can lead to further developmental challenges.
  • * Treatment options like opioid maintenance therapy (OMT) with methadone and buprenorphine aim to support pregnant women but come with risks, indicating a need for better research and a multidisciplinary approach to manage opioid dependence effectively.
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