[Some health parameters in personnel contacting highly enriched uranium].

The authors analysed 20-years and longer observations over health state of personnel having occupational contact with highly enriched uranium. Findings are no determined effects as clinical manifestations of chronic uranium intoxication, presented by most frequently involved systems (hemopoietic, bronchopulmonary) and main organs accumulating uranium (liver, kidneys, bones). Long-term observations revealed malignancies in 11% of the examinees.

[Interactions of radiation factors and smoking in the etiology of lung cancer in workers of atomic enterprises].

It was shown on the basis of retrospective investigation of 500 workers at a nuclear enterprise (162 cases of lung cancer, 338 persons as matching control) that the interaction of external gamma-irradiation (> 2.0 Gy) and the body-burden of 239Pu (> 9.3 kBq) at lung cancer incidence in multiplicative.

[An evaluation of the role of radiation and nonradiation factors in the development of lung cancer in workers at a radiochemical enterprise (1)].

A case-control study using logistic regression included 500 employees of the nuclear works (162 patients with lung carcinoma and 338 healthy controls). After examination of radiation and nonradiation causative factors 5 proved statistically significant. For them the following chance proportions were obtained: smoking 6.

[The "dose-response" mechanism of tumorigenesis in workers of radiochemical plants].

The "dose-response" mechanism has been studied for three main histological types of tumor in a cohort of 500 workers occupationally exposed to different doses of radiation (162 patients with lung cancer and 338 practically healthy persons) using the "case-control" method and multifactorial logic regression procedure. A non-linear threshold dependence was established for incorporated plutonium, with the threshold being at 8 kBq to correspond to 80 kGy. This relationship has been particularly distinct in cases of adenocarcinoma.

[Effect of radiation and other factors on the pathogenesis of various histologic types of lung cancer in workers of radiochemical plants].

Adenocarcinoma frequency in Pu incorporation-related lung cancer patients among plutonium workers was found to be 74% versus 33% in control. Each histological pattern of lung cancer appeared to be related to several etiological factors but in varying degree. Incorporated Pu proved the strongest factor in adenocarcinoma development.