Publications by authors named "Z Munoz"
Background: Invasive ungulates (hoofed mammals), including deer, feral pigs, feral goats, and feral sheep, are known to cause damage to agriculture, property, natural resources, and many other commodities. Most of the information regarding the economic impacts of wild ungulates is from North America, where some of these species are native. To evaluate invasive ungulate damage to livestock producers in the Hawaiian Islands, which have no native ungulates, a survey was distributed to livestock producers across the state.
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- Acute appendicitis is the most common surgical abdominal issue that needs urgent treatment.
- A 78-year-old patient was diagnosed with acute appendicitis caused by a migrated biliary stent obstructing the appendiceal orifice.
- The patient underwent successful nonoperative treatment through endoscopic stent removal and was discharged 72 hours after being admitted.
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- Cancer cells can overexpress CD47, blocking immune responses by preventing macrophages from eliminating them; this study focuses on how HDAC6 inhibitors (like Nexturastat A) can affect this process.
- Researchers tested HDAC6 inhibitors on macrophages to see how these drugs can modify the CD47/SIRPα interaction and increase phagocytosis, with experiments conducted in both lab settings and mouse models.
- The findings showed that HDAC6 inhibitors promote a shift toward antitumoral macrophages, reducing SIRPα levels and CD47 expression, ultimately enhancing the macrophages' ability to phagocytose melanoma cells when combined with anti-CD47 antibodies.
Engineered sites for genetic transformation have simplified transgene insertion in . These strategies include our split hygromycin system (Stevenson et al. 2020) which allows for integration-specific selection of transgenes.
View Article and Find Full Text PDFMelanoma is the least common but deadliest type of skin cancer. Melanomagenesis is driven by a series of mutations and epigenetic alterations in oncogenes and tumor suppressor genes that allow melanomas to grow, evolve, and metastasize. Epigenetic alterations can also lead to immune evasion and development of resistance to therapies.
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