Prioritization of causal genes from genome-wide association studies by Bayesian data integration across loci.

Motivation: Genome-wide association studies (GWAS) have identified genetic variants, usually single-nucleotide polymorphisms (SNPs), associated with human traits, including disease and disease risk. These variants (or causal variants in linkage disequilibrium with them) usually affect the regulation or function of a nearby gene. A GWAS locus can span many genes, however, and prioritizing which gene or genes in a locus are most likely to be causal remains a challenge.

Effect of Sodium Alginate-Bulk Chitosan/Chitosan Nanoparticle Wall Matrix on the Viability of Lactobacillus plantarum Under Simulated Gastrointestinal Fluids.

The viability of probiotic cells decreases during passage through the gastrointestinal tract. The process of probiotics encapsulation with sodium alginate and chitosan polymers was carried out to protect the Lactobacillus plantarum in adverse conditions. Lactobacillus plantarum was entrapped in sodium alginate/chitosan (SA/BChi) and sodium alginate/nano-chitosan (SA/NChi) wall materials.

Process and mechanism modeling of cefotaxime removal from hospital wastewater using pistachio shells based magnetic activated carbon nanoparticles.

Antibiotic residues have been extensively identified in diverse aquatic environments, posing significant health risks to both humans and animals, while also presenting challenges to the environment. Consequently, the imperative need to effectively removal antibiotics from the environment has become a very importance issue. In this study, response surface methodology with central composite design was employed to systematically investigate the effects of key process parameters, on the removal of cefotaxime (CTX) from hospital wastewater using pistachio sells based activated carbon modified with FeCl.

Tissue engineering strategies for ocular regeneration; from bench to the bedside.

Millions globally suffer from visual impairment, complicating the management of eye diseases due to various ocular barriers. The eye's complex structure and the limitations of existing treatments have spurred interest in tissue engineering (TE) as a solution. This approach offers new functionalities and improves therapeutic outcomes over traditional drug delivery methods, creating opportunities for treating various eye disorders, from corneal injuries to retinal degeneration.

The link between the risk of cardiovascular diseases and the intake of different types of dietary carbohydrates in Iranian adults.

Background: The risk of cardiovascular diseases (CVDs) may be influenced by dietary carbohydrates. The aim of this study was to investigate the link between CVDs and the intake of carbohydrates.

Methods: In this cross-sectional study, data was extracted from the Prospective Epidemiologic Research Studies in Iran (PERSIAN) cohort in Sabzevar, Iran.