Publications by authors named "Z Moinfar"
T cell deletional tolerance restricts AQP4 but not MOG CNS autoimmunity.
Proc Natl Acad Sci U S A
July 2023
Aquaporin-4 (AQP4)-specific Th17 cells are thought to have a central role in neuromyelitis optica (NMO) pathogenesis. When modeling NMO, only AQP4-reactive Th17 cells from AQP4-deficient (AQP4), but not wild-type (WT) mice, caused CNS autoimmunity in recipient WT mice, indicating that a tightly regulated mechanism normally ensures tolerance to AQP4. Here, we found that pathogenic AQP4 T cell epitopes bind MHC II with exceptionally high affinity.
View Article and Find Full Text PDFInvestigation of the Relationship between Aspirin-Sensitivity and Poor Response to Medical Management in NSAIDs-exacerbated Respiratory Disease Patients with Sinonasal Polyposis.
Med J Islam Repub Iran
June 2023
Article Synopsis
- NSAID-exacerbated respiratory disease (N-ERD) is a complex condition diagnosed mostly through aspirin challenge tests, which can be risky and time-consuming.
- This study followed patients undergoing standard medical treatment for three months, measuring symptom severity using the Sinonasal Outcome Test (SNOT22).
- Results indicated that aspirin sensitivity in patients was not reliably predicted by the severity of their symptoms or by their improvement after treatment, with both aspirin-sensitive and tolerant patients showing similar symptom reductions.
Objective: Major surgeries and the accompanied acute stress response are associated with poor immune system function and extensive immunologic changes. This study was conducted to compare postsurgery stress responses after transversus abdominis plane (TAP) blocks and epidural anesthesia in patients undergoing laparoscopic cholecystectomy under general anesthesia.
Materials And Methods: Sixty patients who were candidates for laparoscopic cholecystectomy were enrolled in this randomized controlled trial.
Introduction: Mental health problems are common globally, and typically have their onset in adolescence and early adulthood-making youth (aged 11-25) an optimal target for prevention and early intervention efforts. While increasing numbers of youth mental health (YMH) initiatives are now underway, thus far few have been subject to economic evaluations. Here we describe an approach to determining the return on investment of YMH service transformation the pan-Canadian ACCESS Open Minds (AOM) project, for which a key focus is on improving access to mental health care and reducing unmet need in community settings.
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