Genomic insights into racing camels: inbreeding levels and positive selection linked to athletic traits.

Racing dromedary camels are widely distributed across the Arabian Peninsula, predominantly concentrating in its northern and southeastern regions. Phenotypically, they are differentiated from other dromedary types, characterised by their smaller body size, longer limbs, reduced hump size, and thinner chest girth. In this study, the whole genome sequences of 34 racing camels were analysed to assess their genetic relationship with non-racing populations, estimate levels of inbreeding, calculate Wier and Cockerham's fixation index (Fst), assess effective population size (N), and identify candidate regions with signatures of positive selection.

Structural basis of human 20S proteasome biogenesis.

New proteasomes are produced to accommodate increases in cellular catabolic demand and prevent the accumulation of cytotoxic proteins. Formation of the proteasomal 20S core complex relies on the function of the five chaperones PAC1-4 and POMP. Here, to understand how these chaperones facilitate proteasome assembly, we tagged the endogenous chaperones using CRISPR/Cas gene editing and examined the chaperone-bound complexes by cryo-EM.

Exploring neuroglial signaling: diversity of molecules implicated in microglia-to-astrocyte neuroimmune communication.

Effective communication between different cell types is essential for brain health, and dysregulation of this process leads to neuropathologies. Brain glial cells, including microglia and astrocytes, orchestrate immune defense and neuroimmune responses under pathological conditions during which interglial communication is indispensable. Our appreciation of the complexity of these processes is rapidly increasing due to recent advances in molecular biology techniques, which have identified numerous phenotypic states of both microglia and astrocytes.