Identify and analyze ferroptosis-related molecular modules and immune signatures in epilepsy using microarray-based transcriptome profiling and single-cell sequencing.

Currently, the pathogenesis of epilepsy remains poorly understood. Although there is evidence indicating that iron death might play a significant role, its molecular immunological mechanisms are largely unknown. This study was designed to analyze and explore the molecular mechanisms and immunological characteristics of iron death-related genes in epilepsy.

An injectable nanocomposite hydrogel with deep penetration ability for enhanced photothermal and chemotherapy.

The excessive extracellular matrix (ECM) in solid tumors significantly inhibits the deep penetration and homogeneous distribution of nanodrugs, which greatly reduces the therapeutic efficacy. In the present work, an injectable polyelectrolyte hydrogel (CD@IPH) containing collagenase and doxorubicin-loaded polyacrylic acid@polyaniline nanoparticles (DOX@NP) were developed for improved photothermal and chemotherapy. The collagenase is released quickly from the polyelectrolyte hydrogel in the first 12 h, effectively degrading ECM and enhancing the deep penetration and evenly distribution of DOX@NP in tumor tissues.

Robust Mechanically Interlocked Network Ionogels.

Ionogels have attracted considerable attention as versatile materials due to their unique ionic conductivity and thermal stability. However, relatively weak mechanical performance of many existing ionogels has hindered their broader application. Herein, we develop robust, tough, and impact-resistant mechanically interlocked network ionogels (IGMINs) by incorporating ion liquids with mechanical bonds that can dissipate energy while maintain structural stability.

Hyperthermia suppresses the biological characteristics and migration of chicken primordial germ cells.

Primordial germ cells (PGCs) play a crucial role in transmitting genetic information to the next-generation. In chickens, genetically edited PGCs can be propagated and subsequently transplanted into recipient embryos to produce offspring with desired genetic traits. However, during early embryogenesis, the effects of external conditions on PGC migration through the vascular system to the gonads have yet to be explored, which may affect the efficiency of preparing gene-edited chickens.

Successful retrieval of lower limbs artery bone cement embolization resulting from percutaneous vertebroplasty: A rare case report.

Percutaneous vertebroplasty (PVP) is a widely utilized minimally invasive technique originally developed for the treatment of vertebral compression fractures. It has since expanded to treat osteoporotic vertebral compression fractures, pathologic vertebral fractures resulting from primary or secondary spinal tumors, and traumatic spinal fractures. Despite its benefits, PVP is associated with significant complications, the most common of which is bone cement leakage.