Identification of MYOC gene mutation and polymorphism in a large Malay family with juvenile-onset open angle glaucoma.

Purpose: To screen for mutations in the coding region of the myocilin (MYOC) gene in a large Malay family with juvenile-onset open angle glaucoma (JOAG).

Methods: A total of 122 family members were thoroughly examined and screened for JOAG. Venipuncture was conducted.