Publications by authors named "Z Medeiros"
Lymphatic filariasis (LF) is a neglected tropical disease associated with poverty and poor environmental conditions. With the inclusion of vector control activities in LF surveillance actions, there is a need to develop simple methods to identify areas with higher mosquito density and thus a higher consequent risk of transmission. An ecological study was conducted in Igarassu, which is in the metropolitan region of Recife, Pernambuco, Brazil.
View Article and Find Full Text PDFHuman visceral leishmaniasis and polymorphisms in interleukin-coding genes: a systematic review.
J Venom Anim Toxins Incl Trop Dis
October 2024
Article Synopsis
- Visceral leishmaniasis (VL) is a tropical disease caused by a parasite, influenced by environmental and genetic factors, particularly the genetic variations in cytokine genes.
- This systematic review and meta-analysis evaluated the impact of specific single nucleotide polymorphisms (SNPs) in interleukin genes on the susceptibility or resistance to VL, using data from multiple scientific databases.
- The analysis revealed significant associations between SNPs in the IFN-γ and IL-18 genes with VL, suggesting that these genetic variations could influence disease outcomes, while no significant links were found for IL-10 gene SNPs.
Evaluation of Chemokines MIG and IP-10 as Immunological Biomarkers of Human Visceral Leishmaniasis: A Systematic Review.
Trop Med Infect Dis
September 2024
Visceral leishmaniasis (VL) is a neglected tropical disease that is potentially fatal when untreated. Current diagnostic methods have limitations that contribute to ongoing transmission and poor prognosis. Thus, new tests are needed to provide quick, accurate diagnoses and evaluate clinical progression and treatment efficacy.
View Article and Find Full Text PDFArticle Synopsis
- The COVID-19 pandemic was caused by the SARS-CoV-2 virus, leading to serious health issues including severe respiratory problems and potential death, especially in regions with high rates of HIV and Leishmania infantum infections.
- A case study of a 48-year-old woman in Brazil showed she was hospitalized for 36 days with a complicated coinfection of SARS-CoV-2, HIV, and Leishmania infantum, experiencing severe symptoms and concerning lab results, including low oxygen saturation and abnormal blood markers.
- Despite her critical condition and the complications from the coinfection, she was eventually discharged, highlighting the need for more research on how to effectively diagnose and manage patients with similar coexisting infections amid the COVID-19
In 2022, the Pan American Health Organization recommended the intralesional application (IL) of pentavalent antimonials in adult patients with localized cutaneous leishmaniasis (CL) caused by Leishmania (Viannia) braziliensis. Other guidelines differ from that recommendation, considering that infections caused by a Leishmania species that can be associated with increased risk for mucosal leishmaniasis, in particular L. (V.
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