Publications by authors named "Z Majercikova"
Article Synopsis
- Matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) are crucial for cancer progression, affecting cell invasiveness by degrading the extracellular matrix, but their specific roles in brain tumors are not fully understood.
- A study using quantitative real-time PCR found eight deregulated genes in glioblastoma patients compared to those with benign meningiomas, highlighting important differences in tumor aggressiveness.
- Elevated MMP and TIMP protein levels were observed in glioblastoma patients, suggesting these proteins could be key players in gliomagenesis and potential targets for personalized cancer therapies, though further research is needed to confirm the relationship between gene expression and protein levels.
Background: Brain tumors are a heterogeneous group of malignancies characterized by inter- and intratumoral heterogeneity. Among them, the most aggressive and, despite advances in medicine, still incurable remains glioblastoma. One of the reasons is the high recurrence rate of the disease and resistance to temozolomide, a golden standard in chemotherapy of brain tumors.
View Article and Find Full Text PDFDeregulation of signalling pathways that regulate cell growth, survival, metabolism, and migration can frequently lead to the progression of cancer. Brain tumours are a large group of malignancies characterised by inter- and intratumoral heterogeneity, with glioblastoma (GBM) being the most aggressive and fatal. The present study aimed to characterise the expression of cancer pathway-related genes ( = 84) in glial tumour cell lines (A172, SW1088, and T98G).
View Article and Find Full Text PDFBackground: Glioblastoma (GB) is the most common and biologically the most aggressive primary brain tumor of the central nervous system (CNS) in adults. Standard treatment for newly diagnosed GB consists of surgical resection, radiotherapy, and chemotherapy with temozolomide (TMZ). Despite numbers of studies, a resistance to chemotherapy is the major obstacle to successful GB treatment.
View Article and Find Full Text PDFAs the commonest type of cancer in Europe and the third most common type of cancer worldwide, colorectal carcinoma (CRC) poses a challenge for numerous scientific studies. At present, the cause of this disease is remains to be elucidated, but early diagnosis is only one solution to prevent serious health complications. As a structural scaffold, the extracellular matrix (ECM) is in direct contact with tumour cells and significantly interferes with tumour progression.
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