Lymph node macrophages drive immune tolerance and resistance to cancer therapy by induction of the immune-regulatory cytokine IL-33.

Apoptotic cells are immunosuppressive, creating a barrier in cancer treatment. Thus, we investigated immune responses to dying tumor cells after therapy in the tumor draining lymph node (TDLN). A key population responsible for clearing tumor material in the TDLN was medullary sinus macrophages (MSMs).

Protective effect of modafinil in bisphenol A-induced lung injury in rats: roles of SIRT1-dependent signaling pathways.

Background: Bisphenol A (BPA) is an industrial chemical used in manufacturing epoxy resins, polycarbonate plastics. We aimed to evaluate the possible protective effect of modafinil (MOD) in BPA-induced lung injury.

Materials And Methods: Twenty-four adult male albino Wistar rats were divided into four groups: Control group, MOD group: rats received modafinil 10 mg/kg/day for 4 weeks, BPA group: rats received Bisphenol A (500 mg/kg/day) for 4 weeks, MOD/BPA group: rats received MOD+ BPA.

Antioxidant and anti-inflammatory effects of ellagic acid as a new therapy for infection.

Trichinellosis is a widespread food-borne zoonosis, causing mild to severe illness in humans with potential fatality. Its treatment remains challenging due to the side effects and limited efficacy of specific drugs. Therefore, the current study was conducted to assess the therapeutic effects of ellagic acid (EA) alone and combined with albendazole against trichinellosis and its biochemical and pathological alterations in mice.

Atypical Motor-Predominant Presentation of Subacute Combined Degeneration of Spinal Cord Due to Vitamin B12 Deficiency: A Case Report of Stroke Mimicry in the Absence of Classic Symptoms.

Vitamin B12 deficiency is a prevalent condition that can lead to serious neurological disorders, including subacute combined degeneration (SCD) of the spinal cord, which can result in lasting damage if not promptly treated. This report discusses a unique case of a 53-year-old female patient who presented with a one-week history of gait instability and falls, ultimately diagnosed with SCD due to severe vitamin B12 deficiency. Notably, the patient exhibited an atypical presentation, lacking classic symptoms such as paraesthesia and hematologic abnormalities, which often accompany B12 deficiency.