Long-term monotherapy with lamotrigine in newly diagnosed epilepsy in adults.

Lamotrigine (LTG) as both effective against a wide range of seizure types and epileptic syndromes and well tolerated drug is being used in mono--as well as in polytherapy of pharmacoresistant epilepsy. The aim of this study was to evaluate the efficacy, safety and neuropsychological functioning after LTG (mean daily dose: 316 mg) as long-term monotherapy (12 mo) in 24 young adult out-patients (22.5 ys) with newly recognised and not-previously treated epilepsy in an open, non-comparative trial.

The role of posttraumatic intracranial cysts in the pathogeny of late epileptic seizures as exemplified by two patients.

Intracranial cysts are most often found in the lateral sulcus between the cerebral hemispheres and at the midline in the posterior cranial cavity. Covered with the clear or turbid arachnoidea, they are filled with a clear, colorless or slightly yellow cerebrospinal fluid, sometimes they have a considerable size and tend to be an unexpected discovery during an operation for symptoms of a brain tumor. The symptoms depend on the cyst's location and size.