Publications by authors named "Z M E Tawhid"
Article Synopsis
- The IL-17F SNP (rs763780) is linked to increased IL-17F expression and a higher risk of autoimmune diseases, particularly multiple sclerosis (MS) in Egyptian patients.
- A study involving 231 participants found that specific genotypes (CT+CC) and the C allele were significantly more frequent in MS patients compared to healthy controls, especially in females.
- Results indicated that the CT genotype is associated with optic neuritis, and factors like smoking were linked to more frequent MS attacks and higher disability scores (EDSS).
Systemic lupus erythematosus (SLE) susceptibility has a strong genetic component. Genome-wide association studies (GWAS) across trans-ancestral populations show both common and distinct genetic variants of susceptibility across European and Asian ancestries, while many other ethnic populations remain underexplored. We conducted the first SLE GWAS on Egyptians-an admixed North African/Middle Eastern population-using 537 patients and 883 controls.
View Article and Find Full Text PDFPsoriasis is a chronic inflammatory disorder of the skin, with genetic factors reportedly involved in the disease pathogenesis. Numerous studies reported psoriasis candidate genes. However, these tend to involve mostly in the European and Asian populations.
View Article and Find Full Text PDFBackground: There is no report about the association between GATA3 rs3824662 polymorphism and systemic lupus erythematosus (SLE).
Objective: To investigate the possible role of GATA3 rs3824662 polymorphism as a susceptibility risk factor for either adult SLE (aSLE) or pediatric SLE (pSLE) and to evaluate its role in the development of lupus nephritis (LN) in pSLE.
Methods: Typing of GATA3 rs3824662 polymorphism was done using real-time polymerase chain reaction for three groups; 104 pSLE patients, 140 aSLE patients and 436 age- and sex-matched healthy controls.
Objective: To study the relation between CD226 rs763361 gene polymorphism and CD226 serum level and to evaluate their role in susceptibility and disease activity of RA in a cohort of Egyptian individuals.
Methods: The serum level of CD226 was measured using a suitable ELISA kit and the CD226 rs763361 gene polymorphism was typed by PCR-RFLP for 112 RA patients and 100 healthy controls.
Results: Significant association with RA was found with CD226 T allele (OR (95%CI) = 1.