Publications by authors named "Z M Chirenje"
Background: Few investigations have assessed contributions of both vaginal bacteria and proinflammatory immune mediators to human immunodeficiency virus (HIV) acquisition risk in a prospective cohort.
Methods: We conducted a nested case-control study of African women who participated in a randomized placebo-controlled trial of daily oral versus vaginal tenofovir-based preexposure prophylaxis for HIV infection. Vaginal concentrations of 23 bacterial taxa and 16 immune mediators were measured.
Prevalence and factors associated with uptake of pre-exposure prophylaxis amongst women vulnerable to HIV who received HIV antibodies in Antibody Mediated Prevention HVTN703/HPTN081 trial in Harare, Zimbabwe: a cross-sectional study.
BMJ Public Health
July 2024
Introduction: There is limited evidence on pre-exposure prophylaxis (PrEP) uptake post-trial participation for women vulnerable to HIV. This study investigates the prevalence and factors associated with PrEP uptake post-participation in an HIV prevention trial.
Methods: Former Antibody Mediated Prevention (AMP) study participants were invited to the three AMP clinical research sites in Zimbabwe after at least a year of exiting the study.
Article Synopsis
- Safer conception services are essential for HIV sero-discordant couples wanting to conceive, yet there is limited research on their experiences and preferences with various methods.
- A study involving 17 couples in Zimbabwe revealed that choices around safer conception were influenced by desires for intimacy and factors like method familiarity, ease of use, and effectiveness in preventing HIV while achieving pregnancy.
- Participants generally had positive experiences and satisfaction, particularly with ART/VL and PrEP, highlighting the importance of finding suitable methods for safe conception.
Article Synopsis
- Decision-making on childbearing for HIV sero-different couples requires balancing personal desires with perceived risks of HIV transmission, highlighting complex relationship dynamics.
- A study conducted interviews with 17 couples who participated in the SAFER study, exploring their experiences with safer conception methods and the importance of communication and gender roles in their decision-making.
- Findings suggest that safer conception programs need to focus on addressing power imbalances in relationships, enhancing couple communication skills, and providing support from healthcare providers to help couples make informed, safe reproductive choices.
DNA viruses are common in the human population and act as aetiological agents of cancer on a large scale globally. They include the human papillomaviruses (HPV), Epstein-Barr virus (EBV), Kaposi sarcoma-associated herpesvirus (KSHV), hepatitis viruses, and human polyomaviruses. Oncogenic viruses employ different mechanisms to induce cancer.
View Article and Find Full Text PDF