Publications by authors named "Z M Bukhtoiarova"
Under the combined effect of external gamma-irradiation and 239Pu, osteosarcomas occur more frequently and at earlier times, and have more pronounced multicentric pattern of growth and metastatic spreading than occurs with the two agents delivered separately. The difference is in the increased development of tumors and the decreased osteogenesis. Tumor carriers develop atrophy of thymus lymphoid tissue more frequently than normal ones.
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- The study analyzes the activities of alkaline phosphatase (AP) and lactate dehydrogenase (LDG) in rat blood serum and osteogenic sarcomas after exposure to plutonium-239 and gamma radiation.
- It finds a correlation between alkaline phosphatase levels and the histological structure of the sarcomas, as well as patterns in metastases.
- Changes in the isoenzymic spectrum of lactate dehydrogenase in both neoplastic bone tissues and blood serum were noted, particularly an increase in LDG3 and LDG4 fractions and a decrease in LDG5.
The report is concerned with a monolayer culture of bone marrow cells of rats in which optimal blastogenic dose (92.5 kBq/kg) induced osteosarcoma. The cell culture showed an enhanced rate of fibroblast-like cell proliferation (increased number of mitoses and symplasts and larger colonies of cells), apparent signs of radiation injury (pathologic mitoses, chromosome aberrations and gaps) as well as an increase in ploidy.
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