Publications by authors named "Z M Anwar"
Article Synopsis
- A reliable RP-HPLC method with UV detection was developed for the accurate measurement of Voriconazole in pure and gel formulations, using a 50:50 acetonitrile-water mobile phase and a flow rate of 1.0 ml/min.
- The method demonstrated excellent linearity (correlation coefficient = 0.9999) and precision, with a percentage relative standard deviation (RSD) of less than 2.0.
- Robustness was evaluated using variables like flow rate and pH; while flow rate significantly affected drug concentration, the method remained straightforward and suitable for daily quality control with a retention time of under 4 minutes.
Riboflavin (RF) sensitized photooxidation of pyridoxine HCl (PD) in the pH range of 2.0-12.0 has been carried out under UV and visible irradiation in aerobic and anaerobic conditions.
View Article and Find Full Text PDFCapillary zone electrophoresis-immunosubtraction (CZE-IS) is an essential laboratory test in diagnosing plasma cell neoplasms. However, the current interpretation of the test results is subjective. To evaluate CZE-IS in a more precise manner, this study proposed five key indexes, namely sharpness index, light chain index, immunoglobulin G index, immunoglobulin A index, and immunoglobulin M index.
View Article and Find Full Text PDFBreast cancer is a widespread and fatal disease that impacts millions of individuals globally. Pakistan has seen a notable rise in both incidence and mortality rates, ranking among the highest globally alongside the Solomon Islands. The WHO Global Breast Cancer Initiative (GBCI) strives to decrease global mortality by 2.
View Article and Find Full Text PDFAscorbic acid assisted photodegradation of methylcobalamin using corrective irrelevant absorption spectrophotometric assay: A kinetic study.
Spectrochim Acta A Mol Biomol Spectrosc
December 2024
Article Synopsis
- Photodegradation of drug substances can produce both known and unknown products that interfere with analytical results due to absorption at certain wavelengths.
- The study focuses on improving the accuracy of measurements for methylcobalamin (MC) and hydroxocobalamin by applying linear and non-linear methods to correct for irrelevant absorbances during photolytic degradation involving ascorbic acid (AH).
- Methylcobalamin shows first-order degradation kinetics, with the degradation rate being pH-dependent; it peaks at pH 5.0 when in the presence of ascorbic acid, whereas degradation slows down in more alkaline conditions.