Publications by authors named "Z Lohinai"
Background: Colonization of the human gut and tumor tissue by non-pathogenic fungi has emerged as a potential risk factor associated with cancer epidemics. Therefore, we aimed to conduct a systematic review to assess the role of fungal colonization in gastrointestinal (GI) tumors in increasing diagnostic efficiency.
Methods: A PubMed citation search was conducted for publications up to and including March 2023, followed by full-text screening.
Introduction: Changes in the human gut microbiome have been linked to various chronic diseases, including chronic obstructive pulmonary disease (COPD). While substantial knowledge is available on the genomic features of fecal communities, little is known about the microbiome's transcriptional activity. Here, we analyzed the metatranscriptomic (MTR) abundance of MetaCyc pathways, SuperPathways, and protein domain families (PFAM) represented by the gut microbiome in a cohort of non-small cell lung cancer (NSCLC) patients with- or without COPD comorbidity.
View Article and Find Full Text PDFBackground: Advanced-stage non-small cell lung cancer (NSCLC) poses treatment challenges, with immune checkpoint inhibitors (ICIs) as the main therapy. Emerging evidence suggests the gut microbiome significantly influences ICI efficacy. This study explores the link between the gut microbiome and ICI outcomes in NSCLC patients, using metatranscriptomic (MTR) signatures.
View Article and Find Full Text PDFBackground: This study investigates the dose-response relationship of acetylcholine (ACh) on healthy human gingival blood flow (GBF). Understanding this dose-response relationship contributes to studying vasodilatory mechanisms in various pathological conditions.
Methods: The study involved 22 young healthy men (21 - 32 years) to investigate the dose-response relationship of ACh on GBF.
Article Synopsis
- This review explores the gut-lung axis, highlighting its anatomy, function, and clinical relevance, focusing on how the gastrointestinal and respiratory systems communicate and maintain balance.
- It emphasizes the role of the gut microbiome and mucosa-associated lymphoid tissue (MALT) in immune responses, linking issues like "leaky gut" to systemic inflammation and respiratory problems.
- The review also addresses the significance of the gut-lung axis in cancer, specifically lung cancer, advocating for interdisciplinary research to improve our understanding and treatment approaches in health and disease.