Drug Development.

Background: Global epidemiological studies involving over nine million participants have shown a 35% lower incidence of Alzheimer's Disease (AD) in older cancer survivors compared to those without a history of cancer. This inverse relationship, consistent across recent studies with methodological controls, suggests that cancer itself, rather than cancer treatments, may offer protective factors against AD. This insight opens avenues for novel therapeutic strategies targeting early AD by harnessing cancer-associated protective factors.

Phthalates in the environment of China: A scoping review of distribution, anthropogenic impact, and degradation based on meta-analysis.

Phthalates (PAEs) are a group of endocrine-disrupting environmental chemicals (EEDs) that pose significant risks to human health. PAEs are widespread in various environmental media, including air, dust, water, and soil, and are subject to both horizontal and vertical migration. Human activities significantly influence the distribution of PAEs, yet current research on this relationship remains limited.

Intestinal flora composition and fecal metabolic phenotype in elderly patients with sleep disorders combined with type 2 diabetes.

Objectives: This study aimed to determine whether type 2 diabetes (T2D) is an independent risk factor for sleep disorders in the elderly and explore the possible intestinal flora factors of sleep disorders combined with T2D in this population.

Methods: All hospitalized patients with sleep disorders aged ≥65 years between June and November 2023 were retrospectively analyzed, and they were divided into a sleep disorder group ( = 134) and a control group ( = 109). The logistic regression method was utilized to clarify the causal relationship between T2D and sleep disorders.

Intravenous lidocaine decreased the incidence of SRAEs for ERCP procedures in elderly frailty patients, a randomized controlled trial.

Objectives: Elderly frailty patients are at particular risk of sedation-related adverse events (SRAEs) during sedation. This study aimed to assess whether intravenous lidocaine could reduce the incidence of SRAEs in elderly frailty patients undergoing endoscopic retrograde cholangiopancreatography (ERCP).

Methods: A total of 210 elderly frailty patients scheduled for ERCP were randomly divided into two groups: lidocaine and control.

PRAF2 as a novel biomarker for breast cancer with machine learning and experimentation validation.

Background: Breast cancer (BC) is the most prevalent malignancy in women. Potential therapeutic targets for BC are of great significance. In our previous study, we found that prenylated rab acceptor 1 domain family member 2 (PRAF2) is an oncogene in BC.