Thermally Conductive Shape-Stabilized Phase Change Materials Enabled by Paraffin Wax and Nanoporous Structural Expanded Graphite.

Paraffin wax (PW) has significant potential for spacecraft thermal management, but low thermal conductivity and leakage issues make it no longer sufficient for the requirements of evolving spacecraft thermal control systems. Although free-state expanded graphite (EG) as a thermal conductivity enhancer can ameliorate the above problems, it remains challenging to achieve higher thermal conductivity (K) (>8 W/(m·K)) at filler contents below 10 wt.% and to mitigate the leakage problem.

Graphene-Integrated Microbolometer Array Imaging System: A Novel Approach for Fast and Sensitive Terahertz Detection in Biomedical Applications.

Existing biomedical imaging modalities are often restricted by their substantial size, high costs, and potential risks associated with ionizing radiation exposure. Given these challenges, there is an urgent need for innovative imaging systems that not only excel in detection performance but are also compact, cost-effective, and ensure safety for biomedical applications. In response to these requirements, our research introduces an advanced terahertz (THz) microbolometer array imaging system (MAIS), specifically engineered for biomedical detection.

Phase I Clinical Trial of Autologous Hematopoietic Stem Cell Transplantation-Supported Dose-Intensified Chemotherapy With Adebrelimab as First-Line Treatment for Extensive-Stage Small Cell Lung Cancer.

Background: Small cell lung cancer (SCLC) is initially highly sensitive to chemotherapy, which often leads to significant tumor reduction. However, the majority of patients eventually develop resistance, and the disease is further complicated by its "cold" tumor microenvironment, characterized by low tumor immunogenicity and limited CD8+ T cell infiltration. These factors contribute to the poor response to immunotherapy in many cases of extensive-stage SCLC (ES-SCLC).

Genetic and pharmacological targeting of HINT2 promotes OXPHOS to alleviate inflammatory responses and cell necrosis in acute pancreatitis.

The necrosis of pancreatic acinar cells is a key molecular event in the progression of acute pancreatitis (AP), with disturbances in mitochondrial energy metabolism considered to be a direct causative factor of acinar cell necrosis. Histidine triad nucleotide-binding protein 2 (HINT2) has been implicated in the development of various diseases, whereas its involvement in the progression of AP remains unclear. This study aims to investigate the role of HINT2 in AP.