Publications by authors named "Z L Nelson"
Article Synopsis
- Traditional clinical guidelines often mismatch the strength of recommendations with the quality of evidence, prompting the need for improvement in the field of urinary tract infections (UTIs).
- The objective was to create a comprehensive guideline that aligns evidence and recommendations better, utilizing a systematic review involving 54 experts across 12 countries who analyzed 914 articles on various aspects of UTIs.
- Only 6 out of 37 questions could be clearly recommended based on strong evidence, while the rest resulted in clinical reviews outlining the risks and benefits of existing approaches.
Purpose: Sequencing-based genetic testing often identifies variants of uncertain significance (VUS) or fails to detect pathogenic variants altogether. We evaluated the utility of RNA sequencing (RNA-seq) to clarify VUS or identify missing variants in a clinical setting.
Methods: Over a 2-year period, genetics providers at a single institution referred 26 cases for clinical RNA-seq.
Article Synopsis
- PI4KA-related disorder is marked by a variety of neurological and gastrointestinal issues, including spasticity, developmental challenges, and recurrent infections, with specific attention given to the impact on B-cell function and immunodeficiency in some patients. * -
- The study involved analyzing 13 patients with PI4KA variants, revealing common traits such as B-cell deficiency and hypogammaglobulinemia, alongside significant changes in B-cell subsets and functioning due to metabolic disruptions. * -
- Findings indicate that mutations in PI4KA lead to disturbances in lipid production and metabolic pathways in B cells, fostering mitochondrial dysfunction and abnormal immune responses, suggesting a critical role of PI4KA in B-cell differentiation and health. *
Cells continuously remodel their intracellular proteins with the monosaccharide O-linked N-acetylglucosamine (O-GlcNAc) to regulate metabolism, signaling, and stress. This protocol describes the use of GlycoID tools to capture O-GlcNAc dynamics in live cells. GlycoID constructs contain an O-GlcNAc binding domain linked to a proximity labeling domain and a subcellular localization sequence.
View Article and Find Full Text PDFInsect behavior is coordinated mainly by smell through the diverse odor-binding proteins (OBP) that allow them to identify and recognize their environment. Sensory information collected through smell is then analyzed and interpreted in the brain, allowing for correct insect functioning. The behavior of honeybees ( L.
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