Deciphering the roles of non-coding RNAs in liposarcoma development: Challenges and opportunities for translational therapeutic advances.

Liposarcoma is one of the most prevalent forms of soft tissue sarcoma, and its prognosis is highly dependent on its molecular subtypes. Non-coding RNAs (ncRNAs) like microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) can bind various cellular targets to regulate carcinogenesis. By affecting the expressions and activities of their downstream targets post-transcriptionally, dysregulations of miRNAs can alter different oncogenic signalling pathways, mediating liposarcoma progression.

Longitudinal Relations Between Adolescent Self-Esteem and Mental Health Concerns: The Mediation of Self-Control and Moderation of Parental Autonomy Support.

Introduction: Adolescents' self-esteem is often associated with their mental health, and believed to be a protective factor against depression, anxiety, and stress. However, the underlying mechanisms of this relationship warrant further exploration. Employing a longitudinal design, this study investigates the relations between self-esteem and mental health in adolescents, considering the mediating influence of self-control and the moderating effect of parental autonomy support.

iPSC-derived human sensory neurons reveal a subset of TRPV1 antagonists as anti-pruritic compounds.

Signaling interplay between the histamine 1 receptor (H1R) and transient receptor potential cation channel subfamily V member 1 (TRPV1) in mediating histaminergic itch has been well-established in mammalian models, but whether this is conserved in humans remains to be confirmed due to the difficulties in obtaining human sensory neurons (SNs) for experimentation. Additionally, previously reported species-specific differences in TRPV1 function indicate that use of human SNs is vital for drug candidate screening to have a higher chance of identifying clinically effective TRPV1 antagonists. In this study, we built a histamine-dependent itch model using peripheral SNs derived from human induced pluripotent stem cells (hiPSC-SNs), which provides an accessible source of human SNs for pre-clinical drug screening.

Overlooked Impact of Moisture on the Stability of Printing Ink and Its Impact on Recycled Low-Density Polyethylene (LDPE) Quality.

Printing inks, composed of binders, pigments, and additives, are essential components in plastic packaging but complicate recycling due to plastic contamination and degradation. While polyolefins are resistant to hydrolytic degradation, moisture generated from upstream cleaning processes, which is often ignored, can accelerate the degradation of ink binders, affecting the recyclate quality. This study has examined the impact of 3 wt.

Endoscopic nasal multilevel skull base reconstruction combined with lumbar cistern drainage in the treatment of infection caused by cerebrospinal fluid leakage: A case report.

Rationale: Traumatic cerebrospinal fluid leakage can cause complications such as meningitis, ventriculitis and brain abscess. It is necessary to formulate individualized treatment strategies, such as the use of antibiotics and skull base reconstruction methods. The application of nasal septum mucosal flap can significantly reduce the incidence of cerebrospinal fluid leakage.