Degenerative Disease Diagnosis and Analysis Based on Tissue Specificity of DNA Methylation.

The tissue specificity of DNA methylation refers to the significant differences in DNA methylation patterns in different tissues. This specificity regulates gene expression, thereby supporting the specific functions of each tissue and the maintenance of normal physiological activities. Abnormal tissue-specific patterns of DNA methylation are closely related to age-related diseases.

Cyanamide-Based Cyclization Reactions for Nitrogen-Containing Heterocycles Synthesis.

Nitrogen-containing heterocycles, such as indoles and quinolines, serve as the key scaffolds in numerous pharmaceuticals, pesticides, and natural products. The synthesis methods of nitrogen-containing heterocycles show significant scientific and industrial value. As a chemical intermediate featuring dual functional groups, cyanamide plays a crucial role in organic synthesis, directly affecting the development of new drugs and the design of new materials.

Polysplenia syndrome associated with multisystem malformation: A rare case report.

Polysplenia syndrome is a rare congenital disease with multiple systemic developmental abnormalities. Their occurrence and development are closely related to embryonic development. The prognosis of the disease depends on its anatomical structure, and the presence or absence of concomitant cardiac malformations also has a prognostic impact.

Through-Space Charge Transfer Dynamic Mechanism in V-Shaped Flexible Carbazole Aromatic Imides Dyads.

Cofacial electron donor-acceptor dyads exhibiting through-space charge-transfer (TSCT) characteristics are widely employed in the development of optoelectronic functional materials. The flexible molecular frameworks between the electron donor and acceptor components allow dynamic modulation of electronic coupling, influenced by excited-state structural relaxation or intermolecular interactions, thereby affecting the charge-transfer (CT) dynamics and the emission properties of TSCT states. In this work, we examine the TSCT dynamic processes of two electron donor-acceptor dyads, CzPhNI and CzPhPI formed by ortho-substitution of phenyl linkage with V-shaped flexible TSCT structures using carbazole as donor and naphthalimide or phthalimide as acceptor.

Interfacial mechanisms of enhanced photoluminescence in AgI-doped red light emitting perovskite quantum dot glass.

Red light emitting perovskite quantum dot (PQD) glass, with narrow-band emission and excellent stability, holds great potential for applications in liquid crystal displays. However, its low photoluminescence quantum yield (PLQY) remains the biggest obstacle limiting its practical application. Additionally, the mechanism behind the enhancement of the PLQY is not well understood, which restricts the further improvement of the PLQY in red light emitting PQD glass.