Publications by authors named "Z Khaleeli"
Article Synopsis
- The study evaluated the effectiveness of the 2023 myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) criteria in diagnosing inflammatory demyelinating conditions in both adults and children.
- It analyzed data from 1,879 patients, confirming MOGAD in 16% of those tested, with follow-up averaging 3.6 years.
- The new diagnostic criteria demonstrated high sensitivity (96.5%) and specificity (98.9%), with MOG-Ab testing showing slightly lower specificity in adults, indicating the new criteria may improve diagnosis accuracy.
Objective: To report on safety and effectiveness of subcutaneous cladribine (Litak) in multiple sclerosis (MS) patients.
Methods: Litak was offered to MS-patients irrespective of disease course. Litak 10 mg was administered for 3-4 days during week 1.
Tuberculosis (TB) may affect the nervous system in many ways. We describe an immunocompetent teenage girl with lymph node TB who had first presented with bilateral optic neuritis. Detailed history identified features inconsistent with immune-mediated optic neuritis.
View Article and Find Full Text PDFAquaporin-4 and myelin oligodendrocyte glycoprotein antibodies in immune-mediated optic neuritis at long-term follow-up.
J Neurol Neurosurg Psychiatry
September 2019
Objectives: To re-evaluate serum samples from our 2007 cohort of patients with single-episode isolated ON (SION), recurrent isolated ON (RION), chronic relapsing inflammatory optic neuropathy (CRION), multiple sclerosis-associated ON (MSON) and neuromyelitis optica (NMO).
Methods: We re-screened 103/114 patients with available serum on live cell-based assays (CBA) for aquaporin-4 (AQP4)-M23-IgG and myelin-oligodendrocyte glycoprotein (MOG)-α1-IgG. Further testing included oligoclonal bands, serum levels of glial fibrillar acidic and neurofilament proteins and S100B.
Background: Structural cortical networks (SCNs) reflect the covariance between the cortical thickness of different brain regions, which may share common functions and a common developmental evolution. SCNs appear abnormal in neurodegenerative conditions such as Alzheimer's and Parkinson's diseases, but have never been assessed in primary progressive multiple sclerosis (PPMS).
Objective: The aim of this study was to test whether SCNs are abnormal in early PPMS and change over 5 years, and correlate with disability worsening.