Publications by authors named "Z Kayali"
Article Synopsis
- The study reviews how cirrhosis affects older adults, specifically comparing their survival and disease progression to younger patients with the same condition.
- It analyzes data from 191 patients over 50, separating them into two age groups (50-64 and 65+) and looking at factors like survival times and risk of disease progression.
- Results indicate that older patients (≥ 65 years) have significantly shorter survival times compared to younger patients (50-64 years), with age, male gender, BMI, and decompensation identified as important factors influencing survival.
Background: Selective depletion of T cells expressing LAG-3, an immune checkpoint receptor that is upregulated on activated T cells, has been investigated in pre-clinical models as a potential therapeutic approach in inflammatory and autoimmune diseases where activated T cells are implicated.
Aims: GSK2831781, a depleting monoclonal antibody that specifically binds LAG-3 proteins, may deplete activated LAG-3 cells in ulcerative colitis (UC).
Methods: Patients with moderate to severe UC were randomised to GSK2831781 or placebo.